BraidEra / BioTwin computational drug discovery

What if your hardest target had another way in?

BioTwin works with biology’s shapes, changing states and possible pathways. Built on 8DB, it connects those structures to chemistry, mechanisms and evidence, helping you explore routes a narrower view can miss and choose the next useful experiment.

Runs on regular desktops and laptops.

See what the foundation makes possible Explore scientific capabilities
Scientific illustration of a molecule approaching a narrow entrance to a pocket inside a folded protein.
Find more ways forwardHidden pockets · States · Mechanisms
Keep the evidence connectedProvenance · Confidence · Calibration
Choose the next useful testPrograms · Partnerships · Possibility

01 / Look closer at the method

A different foundation. More revealing questions.

A shape, a changing state and a path through a molecule each carry information that can change a design. BioTwin brings these distinctions into the calculation, then connects the answer to your next research decision.

Scientific illustration of three folded protein states with different pocket shapes.

It fits. Can it get in?

A promising pose still needs an entry route. Examine pocket capacity and access separately before advancing the design.

Compare fit and access

Do the right conditions happen together?

Fit, reactivity and exposure must coincide. Evaluate them within each conformer before combining the results.

See joint ensemble scoring

One assumption changed. What follows?

A revised chemical input can change the argument for a design. Find the recorded chemistry, competition and response decisions that depend on it.

Follow the dependency example

02 / Connected discovery

A constraint can point to a different approach.

In a BioTwin planning example, the absence of an accessible cysteine prompted suggestions for alternative chemistry, allostery, interface engagement and recruitment. Each came with requirements to check. You can start with the obstacle your program faces and investigate approaches you may not have considered.

Conceptual illustration of folded proteins occupying different valleys in a translucent landscape.

No accessible cysteine?

See the candidate plans and the prerequisites that distinguish a suggestion from a viable mechanism.

See the example

Several promising options?

Native order lattices in 8DB support comparisons that preserve options with different strengths. A separate Lp(a) comparison demonstrates this foundation.

See how comparisons work

03 / Research within reach

Serious biological research. Ordinary computers.

BioTwin runs on commodity hardware, including regular desktop computers and laptops. That puts molecular exploration within reach of smaller teams and independent researchers, using the computers they already own.

Start with a target or a question, compare promising routes and carry the evidence into the next step. Choose the analysis and scale to suit your hardware.

See how local research works
Illustrative research workspace with a molecular model on an ordinary laptop; not a BioTwin interface capture.

04 / Connected discovery

From a molecular question to a candidate program.

In the Lp(a) program, BioTwin compared alternative molecular designs and their supporting assumptions, helping define a candidate program and a focused laboratory verification plan.

Scientific illustration of a small molecular structure beside a protein surface, suggesting an attachment opportunity.
Conceptual illustration

Compare alternatives

Examine candidate designs and their supporting assumptions.

Explore the science

Define the next test

Prepare a focused laboratory verification plan.

Explore the science
05 / Connected discovery

Where would you start?

Use BioTwin to search for an opening, develop a molecular hypothesis or challenge the explanation behind a result.

Illustration of two folded protein surfaces meeting around a small molecular connector.
01 /
Find a starting point

The E3 atlas focuses a broad computational search into ligase priorities and proposed recruiter anchors for target-specific investigation.

Explore the E3 work
Illustration of molecular chemistry near a protein surface.
02 /
Follow a promising idea

Connect structure, chemistry, competition and kinetics to ask whether a molecular proposal could work under relevant conditions.

Follow the Lp(a) investigation
Illustration of a folded RNA strand.
03 /
Try a different scientific approach

Explore named methods for protein states, cryptic pockets, RNA structures, covalent chemistry and biological context.

Find a capability

06 / Connected discovery

Choose the biological effect before the format.

Start with the change you want to make: block a protein, remove it, reduce its production or restore its function. BioTwin brings implemented methods, strategy templates and emerging research directions into a shared solution framework.

Compare molecular, genetic and cellular approaches, with current support explained for each.

Explore modalities
Conceptual illustration bringing a folded protein, an RNA strand and a translucent cell into one scene.

07 / Connected discovery

Build on a foundation that keeps the science usable.

8DB gives BioTwin native structures for shapes, paths, states and ordered alternatives. BioTwin’s scientific methods work with those structures while retaining the evidence behind a decision. A new question can build on the work already done.

See how scientific operations and evidence relationships help you investigate alternatives and revisit the assumption that ruled a route out.

Explore the foundation
Scientific illustration showing a protein surface, ribbons and molecular structure as connected perspectives.
08 / Connected discovery

Have a target in mind?

Tell us the target and the decision holding up your program. We can identify relevant methods and define a focused evaluation.

Which target deserves another look?

Bring one target and one decision your current workflow leaves unresolved. Let’s explore which BioTwin capabilities could open a useful route.

Discuss your target