BioTwin · A Digital Fabric company

Run the entire drug discovery program in silico — before the first wet experiment.

BraidEra simulates a drug program end-to-end across every resolution layer — from quantum and atomic structure up through pathway, cell, tissue and organism — and carries cryptographically auditable evidence at every step. Walk in with a target. Walk out with a virtual shelf-ready dossier that converts cleanly into an IND-enabling program. The lab becomes confirmation, not discovery.

Request early access See how it works

Built on the Digital Fabric reality-twin substrate.

Discovery, not just screening

Topology-first modeling surfaces tractable targets and mechanisms that conventional pocket-based screening misses — including disordered and boundary-targetable proteins.

Evidence you can audit

Every prediction carries an evidence tier, a confidence vector, and a falsifiable criterion. Nothing is asserted that can't be traced and challenged.

Cross-scale by construction

One coherent model spans quantum to organism, so a finding at the atomic layer propagates its consequences — and its uncertainty — all the way up.

How it works

Three moves, repeated until the dossier is shelf-ready.

1
Anchor to known science

Every layer is calibrated against published results and reference databases. Predictions start tethered to ground truth, with confidence that reflects the supporting evidence.
2
Simulate end-to-end

Propagate a candidate through every resolution layer. Where the model can do what conventional methods can't, it produces a specific, testable prediction instead of a vibe.
3
Expose and challenge the holes

Open questions are first-class. Each gap is tracked as accepted, assumed, or challenged — and a challenged gap auto-generates the experiment that would falsify it.

Reality is multimodal. No database is — so we built one.

Every other system makes you pick one shape and force the rest of reality to fit it.

A molecule, a regulatory pathway, a cell, and a whole organism are fundamentally different kinds of structure — and the science lives in the dependencies between them. Yet every data system today makes you choose a single model: rows, or documents, or a graph. Fragment reality across incompatible systems and those dependencies vanish in the seams, taking the discoveries hiding inside them along too. BraidEra runs on a computational substrate, built from scratch in Rust, that represents every known data modality natively in one engine — plus new ones, like topological braids. We don't flatten nature to fit the database. We simulate it as it actually is.

Every modality, one substrate

Quantum, chemical, structural, network, and organism-scale state all live as atoms in a single engine — not a graph database bolted onto a document store, with lossy hand-offs between systems that each see only part of the picture.

Modalities no one else has

Path-dependent biology — epigenetic history, regulatory sequence — is modeled as topological braids that preserve the exact order of events. BraidQL operations like PULL_STRAND and EXCISE_CROSSING ask questions that are physically impossible to write in SQL or GraphQL.

Confidence built into the atom

Every atom carries a 7-axis confidence vector at the storage layer itself. The engine refuses to answer beyond its confidence frontier — it surfaces what it doesn't know instead of fabricating it.

PULL_STRAND FROM strand::0 TOP 5
  WITHIN braid::MYCN
  RETURN strand_id;

BraidQL: pull the most load-bearing regulatory strands through the MYCN braid — in order, with the path preserved. There is no way to write this in SQL.

Virtual shelf-ready means falsifiable

"Virtual shelf-ready" is only credible if every claim has a known-science anchor and a path to being proven wrong. BraidEra ties each claim dynamically to its supporting evidence; contradictions propagate through downstream confidence, and the system gets more confident — and more honest about its limits — as more validation lands.

Provenance and reversibility on every result
Per-claim confidence vectors, not single scores
Auto-designed falsification experiments for contested predictions
A living calibration record that compiles as you build

One model, every scale

From electrons to the whole organism — a single coherent substrate.

R0Quantum / electronic

R1Atomic / structural

R2Residue / segment

R3Domain / disorder

R4Complex / oligomer

R5Pathway / network

R6Cellular / phenotype

R7Tissue / ADMET

R8Organism / PK-PD

Bring us a target.

BraidEra is in active development with design partners. If you're working on a hard target — disordered, "undruggable," or resistance-prone — we'd like to hear about it.

Request early access

Or reach the parent team at digital-fabric.com.