Translate exposure into the consequence that matters
Concentration ratios describe distribution. The effect-space calculation asks what those concentrations could do under the target-response model. Saturation can change how much an apparent exposure advantage matters, so local and systemic effects are examined together.
Find a useful region of the design surface
The current model is calibrated to a specific topical program. It asks which modeled dose or design conditions preserve the intended local effect while limiting the modeled systemic effect. The result is conditional on that calibration, not a general safety guarantee for local delivery.
Measure the assumptions before broadening the claim
Use local exposure, systemic exposure and target-response data from the relevant setting. A different tissue, route or intervention needs its own model. Clinical safety and dosing require evidence beyond the computational effect surface.
Use the result to choose the next delivery question
Barrier modeling could explain how exposure changes, while subcellular partitioning could examine where a small molecule accumulates after cell entry. These answer different questions and need separate calibration before being combined.
- Delivery barriers · Identify a modeled barrier controlling tissue exposure. Delivery barriers
- Inside the cell · Investigate compartment-specific small-molecule distribution. Inside the cell