What would make the complex productive?
Choose a target/recruiter/architecture question and separate engagement from productive complex formation and protein removal.
Bifunctional degradation
- Bifunctional E3-recruiting degraders
Recruiter and geometry studies
- In BioTwin today · Explore E3 recruiter opportunities, linker geometry and target–recruiter mechanism questions using connected computational components.
- Development and validation · Current work includes computational mechanism studies and selected E3 evidence workflows. A candidate must separately establish binding, productive complex formation, ubiquitination, degradation and the intended biological effect.
Locate the first untested step
Choose a target, recruiter and architecture question. Test the earliest unresolved step in the degradation mechanism, then determine whether downstream protein removal produces the intended effect.
Methods for recruiter and interface design
Relevant methods; exact support depends on the target, inputs and scientific route.
- E3 Recruiter and Molecular-Glue Mechanism Design · Connect an E3 recruiter or molecular-glue proposal to the distinct evidence needed for recruitment, degradation and function. Read the method
- Tether Conformer Reach and Productive Geometry · Assess a linker from its actual attachment points, conformations and obstacles to determine which architectures merit a productive-geometry test. Read the method
- Constraint-Guided Protein Interface Analysis · Check proposed protein interfaces against supported structural and experimental constraints, and identify what excludes an alternative. Read the method